Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
There is "credible evidence" Justin Bieber fathered a child after a backstage encounter with an older female fan, her lawyers have claimed. 一名女性的律师声称
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
I'm only a child yet I know we are all part of a family, five billion strong, in fact, 30 million species strong and we all share the same air, water and soil -- borders and governments will never change that. 我只是一个小孩，但我知道我们都是一个大家庭的成员，超过60亿人的大家庭，以及超过三千万物种的大家庭，政府和国界永远都无法改变这个事实。
8. “Mad Max: Fury Road”(George Miller)
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Oklahoma City GM Sam Presti, no stranger to deadline deals, pulled off a clean win bysending Cameron Payne, Joffrey Lauvergne and a second-round pick to Chicago in exchange for Taj Gibson and Doug McDermott.
The Sixers are still slowly pivoting from a full-on institutional tank job to trying to be competitive, and the Suns are not expecting to be anything like good. So those two teams are quasi-tanking. They are, at least, not mad about losing.
“If you were going to be betting, you would bet its going to be warmer than 2015,” said Mr Karl.
Trends and targets in antiviral phototherapy
A person walks through snow Tuesday in Belington, West Virginia. Superstorm Sandy buried parts of West Virginia under more than a foot of snow on Tuesday.
三月四日在好莱坞高地中心Mary J. Blige, Miguel, Gael García Bernal, Andra Day, Natalia LaFourcade, Keala Settle, Sufjan Stevens and Common将会演唱自己的原创歌曲来庆贺第90届奥斯卡。
这封情书是寄给一个叫做Clark C Moore，但是现在已经改名为Muhammad Siddeeq先生的，由于这次改名，让这封信找到真正的收件人变得尤为困难。
10.You are Stressed All the Time
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
又或者，今年是一群有跟虐待、性或其他有关的故事要讲的女性。她们其中几个人在我们的页面上分享了“我也是”(#MeToo)的经历。卡洛塔·加尔(Carlotta Gall)讲述了汉达·阿亚里(Henda Ayari)的故事。后者是一名拥有北非血统的法国公民，也是一名反萨拉菲派活动人士。她指控牛津大学某知名教授强奸了她。
Novel biosensing methodologies for ultrasensitive detection of viruses
The 2015 FT Global Executive MBA ranking this year is remarkable for two reasons. Not only is it the FT’s 100th ranking of business schools, but it also marks the first time thataprogramme that includes a mainland Chinese business school has occupied the top position.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Rankings for Greece, Italy, Portugal and Spain fell dramatically because of the impact of the eurozone crisis, while Egypt, Myanmar and Saudi Arabia registered large falls in the wake of recent political and civil turmoil.
ACE2 as a potential therapeutic target for pandemic COVID-19
We learned about a warehouse that is like a mausoleum for endangered species.
7.Thought-Controlled Bionic Legs
Diagnostic technologies for COVID-19: a review
Han emphasized that the risk of infection still remains because college students, who are sexually active, might have unprotected sex because they are susceptible to external influences.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Some of these people have instead reached for issues that feel close to their concerns: trade, crime, the war on drugs, controlling the borders, fear of Islamist terrorism. All are significant in their own right, and create very real fears for many people, but they have also become a means to have a public conversation about what society’s changes mean for white majorities.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
It’s been one of the worst years for investment decision-making on record, almost across the board. No strategy worked consistently, save for the type of shareholder activism that only a handful of Wall Street’s billionaire titans are able to engage in.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Will the S&P 500 finish the year above 2,650
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
专注于新兴市场的基金集团经历了难熬的一年，安本(Aberdeen)和安石(Ashmore)的资产管理规模都严重缩水。新兴市场交易所交易基金(ETF)也遭遇大规模赎回，ETF.com数据显示，投资者从贝莱德(BlackRock)旗下基金iShares MSCI Emerging Markets以及先锋(Vanguard)富时新兴市场(FTSE Emerging Markets)撤出95亿美元。
Influenza neuraminidase: A druggable target for natural products
It is up to other institutions — notably, Congress, courts and media — and the citizens at large now to do so.
Stephen Curry scored 37 points to lead the defending NBA champions to their 12th straight win to open the season, a hard-fought 115-110 victory over the Toronto Raptors on Tuesday night.
“If lenders are too optimistic during market booms and too pessimistic in downturns, that could be a good reason for authorities to set conservative capital requirements,” he suggests. “Higher haircuts might dampen the initial run-ups, but they could also dampen the subsequent fallouts when tides turn.”
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Equally, a three-week interning stint at PwC in the school summer holidays gave her the chance to sample life in a professional services firm. “I didn’t think I would get a place on [PwC’s programme] as I had no business experience,” she says.
Mary J. Blige, Miguel, Gael García Bernal, Andra Day, Natalia LaFourcade, Keala Settle, Sufjan Stevens and Common will perform their original songs at the Dolby Theatre in Hollywood on March 4, when the motion picture academy kicks of its 90th Oscars ceremony.
The role of biosensors in the detection of emerging infectious diseases
3. 丹·韦斯(Dan Weiss)，《14》，Pi Recordings。《14》的内容如此丰富，整张专辑的作曲由鼓手丹·韦斯一手包办：细节丰富的室内乐，前卫的啸叫，新音乐无词人声与北印度音乐。相比这个宏大的音乐参照系，更令人印象深刻的是，韦斯集结了12名同行乐手，把所有音乐元素融汇为流畅的整体。
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Central China's Hubei province surpassed Hebei province for the first time to rank 7th with 3.2 trillion yuan, up 8.1 percent.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
4.Virtual Assistant: 17.6 percent increase
"We'll start with a broad list and then begin to narrow it," Podesta told the Boston Globe. "But there is no question that there will be women on that list."
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Dachis says: 2011 saw a huge bounce for Dominos in brand enthusiasm from their brand relaunch which 2012 just couldn’t match. It’s a shame they can’t redesign their recipes every year.
The job market faces challenges. Some five million Americans have been out of work for six months, raising the risk their skills will erode and make it even harder for them to find jobs down the road. And fears of slowing revenue growth could keep a lid on hiring by companies. About 36% of U.S. executives expect the head count at their firm to fall, according to an October survey by advisory firm CEB, compared with 29% who said that during the summer.[qh]
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
But the impact of corporate stinginess can go beyond simply ruining employees’ lunar new year holiday, possibly coming back to bite employers: 39 per cent of respondents said they would look for work elsewhere if their year-end bonus was not up to snuff, an increase of 2.3 percentage points from 2015.
Inhibition of SARS coronavirus helicase by bismuth complexes
“This has been a miserable year for EM,” said Paul McNamara, investment director of emerging markets at GAM, the Swiss fund house. “There has been a steady bleed out of assets and no one is certain what shape the market might be in this time next week.”
Tiger got to hunt, bird got to fly;
“I don’t think there are any companies that have survived big assaults from two of the biggest beasts in the hedge fund jungle,” says Ms Simpson of Calpers. “He is cool, calm and collected — the corporate exemplar of ‘Keep calm and carry on’.”
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Mr Ravenscroft ended up leaving teaching to found Enabling Enterprise, a body that seeks to bridge the gulf between schools and business by taking pupils out of the classroom and giving them practical projects and visits to businesses, including UBS, the bank, and Freshfields, the law firm.
Here are four memorable designs from the year, including commentary from some of the artists who helped shape the looks.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
The first is to view Asia as a market that has proved resistant to rapid development and will require significant structural and regulatory change before taking off. The second sees the possibility of sudden upside surprise.
伦敦商学院的MBA课程位列欧洲第一，与美国哥伦比亚商学院(Columbia Business School)合办的EMBA课程位列第三，管理硕士课程首次参与排名就跻身前10名。参与管理硕士课程排名是伦敦商学院夺得欧洲榜首的关键因素。
A savings account had been opened in the boy's name and he used those details when signing up for AdWords.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
But that idea did not bring Brexit to the UK or Mr Trump to Washington.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
9. The brain literally starts eating itself when it doesn't get enough sleep. Chronic sleep deprivation causes the 'clearing' process that usually happens when we sleep to kick into hyperdrive, prompting the brain to clear a huge amount of neurons and synaptic connections away.
Huawei, the Chinese technology group, has taken market share from both Apple and Samsung, according to BrandZ.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Artificial pancreas, however, knock insulin into your body automatically. The device looks much like a regular insulin pump, which slips you insulin continuously through your skin, but this one monitors your blood sugar at all times and adjusts itself accordingly. So even when the wearer sleeps, there's no danger of falling into shock if their sugar drops too low.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
There’s nothing worse than a boss who says one thing and does another, and nothing better than one who keeps his word. Just as managers must trust their team, employees must trust their boss to have their best interests at heart。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Most of those surveyed for the report mentioned that positive impacts of social media include socializing with acquaintances and taking in more information.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Recent years have seen a return of the bacterial infection, reaching numbers not seen since the 1960s, with admissions for a primary diagnosis more than doubling between 2010/11 and 2017/18, from 429 to more than 1,300.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
1号 what the fuck: “职场辣妈”的新境界
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
IE商学院的在线MBA持续吸引着高素质的学员。其半数校友在入读时为高管级别，为所有上榜学院中比例最高的。该学院的在线MBA学员在毕业3年后的平均年薪最高，为17.9万美元，比薪资排第二位的（巴布森学院(Babson College)奥林商学院(Olin Business School)）高出约3万美元。
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Although Chinese domestic suppliers have expanded their market share to 32.7% in 2016, the trend was reversed in 2017, as their share shrank to 26.8%, said Qu Daokui, president of China Robot Industry Alliance.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Perhaps it will not catch on in the cut-throat world of Wall Street. Some may see an extended absence as an admission that their jobs are expendable, and that colleagues can survive — and perhaps thrive — without them.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
“常见物乱更名奖”，每年都是我的心头好。几年前，Speedo曾将泳帽改称为 “头发管理系统”(hair management system)。去年，Falke更绝，将一款袜子称作“生活问题解决方案”(Life Performance Solutions)。
A modular microarray imaging system for highly specific COVID-19 antibody testing
201103/129769.shtmlEveryone tells a white lie on occasion, it’s just a question of why. Some white lies save relationships, some ease a hectic situation, and others buy us time. We all do it, so there is no reason to deny it. As long as we aren’t hurting others or breaking the law, these innocent lies can make life more pleasant. Most of these white lies only stretch aninterpretation of what the truth actually is anyways. Here’s a list of the 10most common white lies and why we tell them.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
The average monthly salaries for grads in law, engineering and medical majors are 5,545, 4,512 and 4,500 yuan respectively, slightly down from last year, while graduates with educational and agricultural majors are offered lower pay, at 3,258 and 3,184 yuan respectively.
A child's eye view of life in a Florida motel community.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The study was based on 3,095 questionnaires from 2016 graduates and 1,661 questionnaires from employers across the country.
DNA from the bones matched that of descendants of the king's sister, while the skeleton had the twisted spine and battle injuries consistent with contemporary accounts, said researchers from the University of Leicester.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Format: Some 18 courses, including four electives, are spread out over every other weekend in Chicago, with three residential weeks in Chicago, one week in Hong Kong, and one week in London
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
“不能再采取某些国家先行动，其他国家随后行动的策略，因为时间不多了，”奥斯陆国际气候与环境研究中心(Center for International Climate and Environmental Research)的科学家格伦·P·彼得斯(Glen P. Peters)说。他也参与了这些新数据的编制。“现在需要大家齐心协力。”
Transport Ministry spokesman Xu Chengguang told a news conference that no further signs of life had been found and the chance of finding anyone else alive was "very slim."
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
昔日影坛风光无限米高梅公司重组计划已获得批准，电影公司将由望远镜娱乐公司( Spyglass Entertainment )掌舵再次出发。而MGM也将不会在作为电影电影发行公司，而仅仅是一个制作公司。这使得第二十三部《007詹姆斯-邦德》电影问世日期更加具体化。
Everyone has both, but people tend to be most attached to their “best” identity — the one that offers the most social status or privileges. Successful professionals, for example, often define their identities primarily through their careers.
Who was buried here?
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
We will push forward with structural adjustment in agriculture.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
"He was not on the intelligence services' radar," added the prime minister.
bend的过去式和过去分词 adj. 下定决心的，弯曲的
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
We will make our skies blue again.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Without a cellphone at hand, Sun tried yelling to get the attention of people outside, but no one responded as time passed by.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
Here are five things consumers and investors can count on (probably) in 2015:
Zuckerberg, 31, had the best year of all billionaires, having added 11.2billion dollars to his fortune and moving up from number 16 to six on the list. This is Zuckerberg's and Amazon's Jeff Bezos' first appearance in the top ten of Forbes' annual ranking.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The dollar value of China’s exports fell markedly more than expected last month and import growth more than halved, while revisions to November data erased what had appeared to be a long-hoped-for return to growth for outbound shipments.
The release of Apple's iPhone 6s and 6s Plus models in September led to record sales in China, which accounts for more than a fourth of the company's operating income. Apple, whose products are often viewed as status symbols in China, is in competition not just with its South Korean archrival Samsung, but with the increasingly popular Chinese smartphone makers Huawei and Xiaomi.
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