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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

There is "credible evidence" Justin Bieber fathered a child after a backstage encounter with an older female fan, her lawyers have claimed. 一名女性的律师声称
美国财政部门最新数据表明印度九月份持有的美国政府债券达到800亿美元,十月份减持美国政府债券到775亿美元——这也是三个月来的最低点。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: “爱情骗子”骗财约1200万
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

I'm only a child yet I know we are all part of a family, five billion strong, in fact, 30 million species strong and we all share the same air, water and soil -- borders and governments will never change that. 我只是一个小孩,但我知道我们都是一个大家庭的成员,超过60亿人的大家庭,以及超过三千万物种的大家庭,政府和国界永远都无法改变这个事实。
8. “Mad Max: Fury Road”(George Miller)

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

高中版的霍华德不像NBA版的霍华德那样令人生畏。如此看来,成为一个NBA巨星,霍华德付出了十倍的努力。

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 传统家具业观念束缚致创新争论大
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

低通胀反映出需求趋弱,不利于人们增强对经济转型(从侧重制造业转向侧重消费)的信心,但另一方面,这种局面为中国政府实施刺激措施留出了空间——假如它希望为经济提供更大支持的话。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Oklahoma City GM Sam Presti, no stranger to deadline deals, pulled off a clean win bysending Cameron Payne, Joffrey Lauvergne and a second-round pick to Chicago in exchange for Taj Gibson and Doug McDermott.
The Sixers are still slowly pivoting from a full-on institutional tank job to trying to be competitive, and the Suns are not expecting to be anything like good. So those two teams are quasi-tanking. They are, at least, not mad about losing.
“If you were going to be betting, you would bet its going to be warmer than 2015,” said Mr Karl.
《飞马》

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

A person walks through snow Tuesday in Belington, West Virginia. Superstorm Sandy buried parts of West Virginia under more than a foot of snow on Tuesday.
三月四日在好莱坞高地中心Mary J. Blige, Miguel, Gael García Bernal, Andra Day, Natalia LaFourcade, Keala Settle, Sufjan Stevens and Common将会演唱自己的原创歌曲来庆贺第90届奥斯卡。
这封情书是寄给一个叫做Clark C Moore,但是现在已经改名为Muhammad Siddeeq先生的,由于这次改名,让这封信找到真正的收件人变得尤为困难。
10.You are Stressed All the Time

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

又或者,今年是一群有跟虐待、性或其他有关的故事要讲的女性。她们其中几个人在我们的页面上分享了“我也是”(#MeToo)的经历。卡洛塔·加尔(Carlotta Gall)讲述了汉达·阿亚里(Henda Ayari)的故事。后者是一名拥有北非血统的法国公民,也是一名反萨拉菲派活动人士。她指控牛津大学某知名教授强奸了她。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

The 2015 FT Global Executive MBA ranking this year is remarkable for two reasons. Not only is it the FT’s 100th ranking of business schools, but it also marks the first time thataprogramme that includes a mainland Chinese business school has occupied the top position.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

现在似乎可以放心地预言,2017年余下时间会出现更多噪音、甚少进展,而这将继续对贸易和英国经济造成破坏。
Rankings for Greece, Italy, Portugal and Spain fell dramatically because of the impact of the eurozone crisis, while Egypt, Myanmar and Saudi Arabia registered large falls in the wake of recent political and civil turmoil.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 智能家居或成家居产业发展新趋势
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

We learned about a warehouse that is like a mausoleum for endangered species.
7.Thought-Controlled Bionic Legs

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Han emphasized that the risk of infection still remains because college students, who are sexually active, might have unprotected sex because they are susceptible to external influences.
['spekju.l?tiv]

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

2016年国家公务员考试报名人数已经超过去年,仅周二一天,符合考试条件的报考人员就达到13.2万人以上,这是单日报考人数最高的一天。
Some of these people have instead reached for issues that feel close to their concerns: trade, crime, the war on drugs, controlling the borders, fear of Islamist terrorism. All are significant in their own right, and create very real fears for many people, but they have also become a means to have a public conversation about what society’s changes mean for white majorities.
全球性肥胖
尽管郭晶晶没有宣布自己的退役时间,但在12月份的东亚运动会上,她发表的关于有可能休战一年的声明,却又向人们透露着讯息。种种迹象表明,她与霍启刚的感情已经迈入一个新阶段。除非他们俩对中国农历里所讲的2010年是“寡妇年”这一说法深信不疑,不然我们很有能看到郭小姐变成霍太太。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

It’s been one of the worst years for investment decision-making on record, almost across the board. No strategy worked consistently, save for the type of shareholder activism that only a handful of Wall Street’s billionaire titans are able to engage in.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Will the S&P 500 finish the year above 2,650
莱斯特大学研究人员表示,这副骸骨的DNA同理查三世一名姐妹的后代吻合,而且骸骨的脊柱弯曲,有战争留下的创伤,这都与历史记载吻合。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

[?'din]

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

至于维护全球贸易的自由化,这需要世界各国共同努力,因为天下是天下人的天下。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

芯片的零售价为150美元,但一次只能烤四寸的饼干。如果你用传统的烤箱,在烤箱烤一大批饼干,你也能在30分钟内烤完8到12块饼干,也更加便宜。
3、Negativity
专注于新兴市场的基金集团经历了难熬的一年,安本(Aberdeen)和安石(Ashmore)的资产管理规模都严重缩水。新兴市场交易所交易基金(ETF)也遭遇大规模赎回,ETF.com数据显示,投资者从贝莱德(BlackRock)旗下基金iShares MSCI Emerging Markets以及先锋(Vanguard)富时新兴市场(FTSE Emerging Markets)撤出95亿美元。
n. 按揭,抵押贷款

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

“有个员工把一块上面写着‘我不干了!’的砖头扔进公司窗户。”
It is up to other institutions — notably, Congress, courts and media — and the citizens at large now to do so.
Stephen Curry scored 37 points to lead the defending NBA champions to their 12th straight win to open the season, a hard-fought 115-110 victory over the Toronto Raptors on Tuesday night.
“If lenders are too optimistic during market booms and too pessimistic in downturns, that could be a good reason for authorities to set conservative capital requirements,” he suggests. “Higher haircuts might dampen the initial run-ups, but they could also dampen the subsequent fallouts when tides turn.”
Project management.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Equally, a three-week interning stint at PwC in the school summer holidays gave her the chance to sample life in a professional services firm. “I didn’t think I would get a place on [PwC’s programme] as I had no business experience,” she says.
Mary J. Blige, Miguel, Gael García Bernal, Andra Day, Natalia LaFourcade, Keala Settle, Sufjan Stevens and Common will perform their original songs at the Dolby Theatre in Hollywood on March 4, when the motion picture academy kicks of its 90th Oscars ceremony.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

3. 丹·韦斯(Dan Weiss),《14》,Pi Recordings。《14》的内容如此丰富,整张专辑的作曲由鼓手丹·韦斯一手包办:细节丰富的室内乐,前卫的啸叫,新音乐无词人声与北印度音乐。相比这个宏大的音乐参照系,更令人印象深刻的是,韦斯集结了12名同行乐手,把所有音乐元素融汇为流畅的整体。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Central China's Hubei province surpassed Hebei province for the first time to rank 7th with 3.2 trillion yuan, up 8.1 percent.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

韩云平表示,去年全国的质量监督部门共提交了36000起和违反质量标准有关的案件,涉及金额达23亿人民币(约合3.33亿美元)的货物。
4.Virtual Assistant: 17.6 percent increase
"We'll start with a broad list and then begin to narrow it," Podesta told the Boston Globe. "But there is no question that there will be women on that list."
日本央行行长黑田东彦(Haruhiko Kuroda)表示:“我觉得我们可以对全球前景持谨慎乐观态度。”

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Dachis says: 2011 saw a huge bounce for Dominos in brand enthusiasm from their brand relaunch which 2012 just couldn’t match. It’s a shame they can’t redesign their recipes every year.
The job market faces challenges. Some five million Americans have been out of work for six months, raising the risk their skills will erode and make it even harder for them to find jobs down the road. And fears of slowing revenue growth could keep a lid on hiring by companies. About 36% of U.S. executives expect the head count at their firm to fall, according to an October survey by advisory firm CEB, compared with 29% who said that during the summer.[qh]
欧盟的美洲布局
a不,非,mnes记忆-不记仇-赦免

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

But the impact of corporate stinginess can go beyond simply ruining employees’ lunar new year holiday, possibly coming back to bite employers: 39 per cent of respondents said they would look for work elsewhere if their year-end bonus was not up to snuff, an increase of 2.3 percentage points from 2015.
还有哪对系列电影的荧幕情侣可以像《暮光之城》的克里斯汀?斯图尔特和罗伯特?帕丁森这样成功开创戏路呢?两个人都成为了影坛名角。帕丁森在最新作品《好时光》中延续了他近年来这种让人几乎认不出的造型风格。在《迷失Z城》中,他把自己打扮成胡子蓬乱的眼镜男,如今他又把头发染成亚麻色,变身为一个试图在纽约完美做案,结果却让患有发育性残疾的弟弟(本?萨弗迪饰)被捕的银行抢劫犯。他试图用盗取的钱来给弟弟交保释金,结果麻烦接踵而至。很多的麻烦。除了饰演弟弟一角外,本?萨弗迪还和自己的哥哥约书亚?萨弗迪共同执导了这部电影。《好时光》入围了今年戛纳电影节的主竞赛单元,参与角逐金棕榈奖。该片于11月3日在日本上映,11月17日在英国和爱尔兰上映,11月23日在希腊上映。(资料来源:A24制片公司)

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

“This has been a miserable year for EM,” said Paul McNamara, investment director of emerging markets at GAM, the Swiss fund house. “There has been a steady bleed out of assets and no one is certain what shape the market might be in this time next week.”
简言之,那个时代与当今时代极为相似,一些最哗众取宠的权威人士,要么将其捧上天,要么把其贬得一文不值。
Tiger got to hunt, bird got to fly;
玛戈特·瓦尔斯特伦在20多岁时结束了一段充满暴力的感情。作为外交部长,她正在一个传统上属于男性的领域里挑战各种假定。
“I don’t think there are any companies that have survived big assaults from two of the biggest beasts in the hedge fund jungle,” says Ms Simpson of Calpers. “He is cool, calm and collected — the corporate exemplar of ‘Keep calm and carry on’.”

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Johan Pettersson被授予搞笑化学奖,以表彰其揭示了瑞典小城Andersl?v居民的头发会变绿的原因,因为这里的水中含铜量太大。
倒灌啤酒机是倒啤酒的一种革命性创新方式,节省时间,减少浪费,也令顾客啧啧称奇。
无论从哪个角度看,2014年都是本田汽车公司宁愿忘却或掩盖的一年,看看本田为2015年提出的宏大口号——“本田之年”就知道了。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 盘点2015石材行业八大关键词
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Mr Ravenscroft ended up leaving teaching to found Enabling Enterprise, a body that seeks to bridge the gulf between schools and business by taking pupils out of the classroom and giving them practical projects and visits to businesses, including UBS, the bank, and Freshfields, the law firm.
Here are four memorable designs from the year, including commentary from some of the artists who helped shape the looks.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
From the themed collection: 在非洲卖建材是种什么体验?
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

这就真相了,我同意。
95后对就业的选择更加多元化,也更加青睐工作与兴趣相结合。
[di'pɑ:t]

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

The first is to view Asia as a market that has proved resistant to rapid development and will require significant structural and regulatory change before taking off. The second sees the possibility of sudden upside surprise.
伦敦商学院的MBA课程位列欧洲第一,与美国哥伦比亚商学院(Columbia Business School)合办的EMBA课程位列第三,管理硕士课程首次参与排名就跻身前10名。参与管理硕士课程排名是伦敦商学院夺得欧洲榜首的关键因素。
A savings account had been opened in the boy's name and he used those details when signing up for AdWords.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

But that idea did not bring Brexit to the UK or Mr Trump to Washington.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

8.《生活大爆炸》白板上的公式都是真的

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

9. The brain literally starts eating itself when it doesn't get enough sleep. Chronic sleep deprivation causes the 'clearing' process that usually happens when we sleep to kick into hyperdrive, prompting the brain to clear a huge amount of neurons and synaptic connections away.
Huawei, the Chinese technology group, has taken market share from both Apple and Samsung, according to BrandZ.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

现在,我们来预测一下社交媒体领域在2014年将发生哪些事情。Snapchat会火起来吗?哪些烦人的“推广消息”(Promoted Tweets)会不会持续不断地入侵你的Twitter信息流?你的老板是否将终于学会如何使用Twitter?这五大趋势有望撼动社交网络世界,以及我们在2014年使用社交媒体的方式:
Artificial pancreas, however, knock insulin into your body automatically. The device looks much like a regular insulin pump, which slips you insulin continuously through your skin, but this one monitors your blood sugar at all times and adjusts itself accordingly. So even when the wearer sleeps, there's no danger of falling into shock if their sugar drops too low.
2.这里没有人能够回答你问的任何关于击剑的问题。还是去google一下吧。
trademark

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 瓷砖企业在固步自封中丧失主动权
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

最佳豪华汽车品牌:保时捷
There’s nothing worse than a boss who says one thing and does another, and nothing better than one who keeps his word. Just as managers must trust their team, employees must trust their boss to have their best interests at heart。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Most of those surveyed for the report mentioned that positive impacts of social media include socializing with acquaintances and taking in more information.
该协会的首席经济学家Lawrence Yun预计,到今年年底,30年期固息抵押贷款的平均利率将触及5.5%,高于去年底的4.5%和去年上半年的3.5%。抵押贷款利率在短期内如此急剧上升,可能会损害购房者的承受能力,甚至吓退更多购房者。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Recent years have seen a return of the bacterial infection, reaching numbers not seen since the 1960s, with admissions for a primary diagnosis more than doubling between 2010/11 and 2017/18, from 429 to more than 1,300.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

1号 what the fuck: “职场辣妈”的新境界
公司:撒马源公司
北方高等商学院毕业生的平均薪酬水平为10.5万美元,排名第11位,而斯隆毕业生为14.36万美元。他们的薪资增幅为79%,排名第七。
['fig?]

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: 租房如何避开“隐形杀手”?
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

IE商学院的在线MBA持续吸引着高素质的学员。其半数校友在入读时为高管级别,为所有上榜学院中比例最高的。该学院的在线MBA学员在毕业3年后的平均年薪最高,为17.9万美元,比薪资排第二位的(巴布森学院(Babson College)奥林商学院(Olin Business School))高出约3万美元。
如果此时打断老师讲课不太合适,你可以快速记下自己的问题,以免忘记,之后再问老师。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

● “奥巴马总统证实,如果特朗普当选他将拒绝离开白宫”
第48届美国乡村音乐学院奖获奖名单:
节目28 歌曲《留声2012》①《滴答》(表演者:侃侃、李晨)②《我的歌声里》(表演者:曲婉婷、杜淳)

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 年轻人,下一站去哪?
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Although Chinese domestic suppliers have expanded their market share to 32.7% in 2016, the trend was reversed in 2017, as their share shrank to 26.8%, said Qu Daokui, president of China Robot Industry Alliance.
007电影中,反派人物往往没有自己的主题曲,但是《金枪人》中克里斯多弗·李扮演的暗杀者出场时有一段轻快动人的绝妙曲调,衬托出暗杀者如地狱使者般帅气冷酷。LuLu的演唱完全演绎出这个反派斯卡拉孟加的过人之处。即使这首歌在今天来说欢快得有点可笑,但这也增添了它的魅力。
该工作室称,他们已经采取了措施,因为这个男孩拒绝删除发布在youtube上的视频,而在这个视频中他向人们介绍了如何去使用这个软件。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Perhaps it will not catch on in the cut-throat world of Wall Street. Some may see an extended absence as an admission that their jobs are expendable, and that colleagues can survive — and perhaps thrive — without them.
无论是左翼还是右翼,他们都标榜自己是反精英的大众代表和不合适的局外人,并作为魅力领导人与追随者密切联系,他们往往通过弥天大谎来操纵这种联系,用以谋求自己的进步;他们威胁既有的行为准则和约束性制度,把这些准则和制度描述为他们所代表的民意的敌人。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

教育行业基本上还未受到在线服务交付的影响——但可能会在2018年经历戏剧性的变化。
“常见物乱更名奖”,每年都是我的心头好。几年前,Speedo曾将泳帽改称为 “头发管理系统”(hair management system)。去年,Falke更绝,将一款袜子称作“生活问题解决方案”(Life Performance Solutions)。
单词refrigerator 联想记忆:

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

回顾今天这场比赛,胜利来得并不容易。猛龙队曾一举逆转了18分的劣势,并在最后时刻拥有球权并只落后1分。但是最终,后卫凯尔·洛瑞被吹罚了一次进攻犯规,而库里依靠两记罚球为勇士队锁定胜局。
201103/129769.shtmlEveryone tells a white lie on occasion, it’s just a question of why. Some white lies save relationships, some ease a hectic situation, and others buy us time. We all do it, so there is no reason to deny it. As long as we aren’t hurting others or breaking the law, these innocent lies can make life more pleasant. Most of these white lies only stretch aninterpretation of what the truth actually is anyways. Here’s a list of the 10most common white lies and why we tell them.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

或许不会是一个超新星,但是会有好球员快速地把他们拉回正轨,比我们之前讨论的其他队伍都要快。打完这个赛季,还完之前的债,然后就可以潇洒甩头,大步向前了。
《财富》美国500强公司美国电话电报公司(AT&T))也于3月份批准了回购至多3亿股股票的计划,价值约105亿美元。这项回购计划是它过去三年中宣布的第四项回购计划。这家公司自从2012年开始股票回购至今,总计已经回购了7.75亿股的股票。
因特尔:新员工红地毯

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

在其他地方,澳大利亚最近推出了提高基金定价透明度的改革措施,这推动了ETF的快速增长。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

The average monthly salaries for grads in law, engineering and medical majors are 5,545, 4,512 and 4,500 yuan respectively, slightly down from last year, while graduates with educational and agricultural majors are offered lower pay, at 3,258 and 3,184 yuan respectively.
A child's eye view of life in a Florida motel community.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

The study was based on 3,095 questionnaires from 2016 graduates and 1,661 questionnaires from employers across the country.
DNA from the bones matched that of descendants of the king's sister, while the skeleton had the twisted spine and battle injuries consistent with contemporary accounts, said researchers from the University of Leicester.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

但是亚利桑那州的经济前景现在已经大为好转,随着住房市场的稳定,失业率在5月份降至7.8%,创下经济衰退后的新低。为了评选今年的美国最适宜经商的州,我们评估了35项指标以判断哪些州的经商条件最佳,哪些最差,这些指标中就包括就业预期。根据穆迪分析公司(Moody’s Analytics)的统计,在今后五年中,亚利桑那州的就业增长速度预计将达到每年3%。到2017年,亚利桑那州增长的就业岗位预计每年将把家庭收入提高3.6%,在全美各州中位居第二,仅次于伊利诺伊州。亚利桑那州的就业增长和经济增长保持同步,穆迪预计该州的经济增长速度为每年4.6%,达到美国的最佳水平。
Format: Some 18 courses, including four electives, are spread out over every other weekend in Chicago, with three residential weeks in Chicago, one week in Hong Kong, and one week in London

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

“不能再采取某些国家先行动,其他国家随后行动的策略,因为时间不多了,”奥斯陆国际气候与环境研究中心(Center for International Climate and Environmental Research)的科学家格伦·P·彼得斯(Glen P. Peters)说。他也参与了这些新数据的编制。“现在需要大家齐心协力。”
Transport Ministry spokesman Xu Chengguang told a news conference that no further signs of life had been found and the chance of finding anyone else alive was "very slim."

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

code

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

昔日影坛风光无限米高梅公司重组计划已获得批准,电影公司将由望远镜娱乐公司( Spyglass Entertainment )掌舵再次出发。而MGM也将不会在作为电影电影发行公司,而仅仅是一个制作公司。这使得第二十三部《007詹姆斯-邦德》电影问世日期更加具体化。
Everyone has both, but people tend to be most attached to their “best” identity — the one that offers the most social status or privileges. Successful professionals, for example, often define their identities primarily through their careers.
Who was buried here?
deprivation

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

We will push forward with structural adjustment in agriculture.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

"He was not on the intelligence services' radar," added the prime minister.
GoldSeek.com的这个标题发出了红色警报。在评估另外20名专家跟踪的20种周期之后,它总结道:“很多周期表明股市的调整或崩溃已经临近……未雨绸缪是很重要的。在‘窗口’关闭之前,你仍有一些时间!”
bend的过去式和过去分词 adj. 下定决心的,弯曲的

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

We will make our skies blue again.
举例来说,新浪微博就一直提供推特所不具备的一些功能,尤其是评论功能,让众多用户得以在别人发表的微博下发表自己的见解。拥有逾7亿用户的腾讯QQ即时信息服务也有众多附加功能,比如可以让用户改换形象的“皮肤”,同时QQ还是腾讯为其他产品和服务做广告的渠道。新浪拒绝置评。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Without a cellphone at hand, Sun tried yelling to get the attention of people outside, but no one responded as time passed by.
ZnS#k]Z047gSW1juv]

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

上班迟到,休息后又迟回工作岗位表现出来的是一种傲慢、随便的工作态度。 因此,快速或者甚至是稍微提前一点进入工作状态说明你有时间观念,你确实很在乎工作和别人时间。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

让爱情多姿多彩:荷兰培育出彩虹玫瑰(图)
单词refrigerator 联想记忆:
大多数企业家(78%)利用储蓄或依赖朋友和家人来筹集全部或部分启动资金。四分之三的企业家也使用天使融资来作为资金来源。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

单词deputy 联想记忆:
Here are five things consumers and investors can count on (probably) in 2015:
vi. 流通,循环,传播
Zuckerberg, 31, had the best year of all billionaires, having added 11.2billion dollars to his fortune and moving up from number 16 to six on the list. This is Zuckerberg's and Amazon's Jeff Bezos' first appearance in the top ten of Forbes' annual ranking.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

英国《金融时报》2017年高管教育排行榜列出了全球85个最佳定制课程和75个最佳开放课程。排名主要基于学员和客户的满意度以及学校收入增长、国际化程度和师资多样性等指标。
你翻上去找第十二条,然后默默地笑自己....

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 用好“新房保险”这把伞
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

The dollar value of China’s exports fell markedly more than expected last month and import growth more than halved, while revisions to November data erased what had appeared to be a long-hoped-for return to growth for outbound shipments.
3、全面放开二孩政策
The release of Apple's iPhone 6s and 6s Plus models in September led to record sales in China, which accounts for more than a fourth of the company's operating income. Apple, whose products are often viewed as status symbols in China, is in competition not just with its South Korean archrival Samsung, but with the increasingly popular Chinese smartphone makers Huawei and Xiaomi.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

中国富人近年来对岛屿表现出越来越浓厚的兴趣。
学员平均年龄:费城班33岁,旧金山班36岁

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